MK677 Buy — Ibutamoren, Research-Grade
MK677 (Ibutamoren, MK-0677) — the most studied orally active GH secretagogue. Independently tested to ≥99% purity via HPLC and Mass Spectrometry. Triple-verified: identity, purity and concentration every batch. 50ml — 1,250mg total. Free US shipping over $100.
Third-Party COA
USA Manufactured
50ml · 1,250mg Total
Free Shipping $100+
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4.94 / 5 — 847 verified research reviews
Research Compound Overview
MK677 Buy — What You Need to Know Before Ordering
MK677 (Ibutamoren, MK-0677) is a potent, orally active, non-peptide ghrelin receptor agonist and growth hormone secretagogue developed by Merck. It stimulates the pituitary gland to release GH and IGF-1 endogenously — no injection required. When you buy MK677, the most critical factors are purity, concentration verification, and COA transparency. Here is exactly what Chemyo provides on every order.
AdooQ sells Ibutamoren Mesylate (MK677) as a biochemical reagent in 5mg–100mg vials at approximately $8–16 per milligram — designed for in vitro cell assay work. Chemyo sells MK677 free base as a practical research compound: 50ml at 25mg/ml, delivering 1,250mg total at $0.04/mg. That is a 400x better price per milligram, with triple verification (identity + purity + concentration) and same-day USA dispatch. Two entirely different products for two entirely different research scales.
AdooQ sells MK677 Mesylate (CAS 159752-10-0) — the salt form with enhanced water solubility, preferred for in vitro assay preparation. Chemyo sells MK677 free base (CAS 159634-47-6) — the form used in all published Phase II and III clinical trials and the standard for oral and subcutaneous research protocols. If you are buying MK677 for practical research protocols, free base is the correct form.
MK677 Product Specifications at Chemyo
| Compound Name | MK677 (Ibutamoren, MK-0677, Ibutamoren free base) |
| Also Known As | MK-677, MK 677, Ibutamoren, Nutrobal |
| CAS (free base) | 159634-47-6 |
| CAS (mesylate) | 159752-10-0 (AdooQ form — not sold by Chemyo) |
| Class | GH Secretagogue / Ghrelin Receptor Agonist |
| Molecular Formula | C₂₇H₃₆N₄O₅S |
| Molecular Weight | 528.66 g/mol |
| Purity (Chemyo) | ≥99% HPLC verified |
| Identity Testing | Mass Spectrometry — every batch |
| Concentration Testing | Independent lab — every batch |
| Bottle Volume | 50ml (vs 30ml industry standard) |
| Concentration (liquid) | 25mg/ml |
| Total MK677 per bottle | 1,250mg total |
| Half-Life | ~24 hours (oral, animal models) |
| Available Forms | Liquid 25mg/ml · Capsules 10mg × 60ct · Powder 1g |
| Intended Use | Research purposes only — not for human use |
Mechanism of Action
How MK677 Works — The GH Secretagogue Pathway
MK677’s fully oral mechanism is what makes it unique among all GH research compounds. No injection, no reconstitution — and a ~24-hour half-life for once-daily research protocols.
Vendor Comparison
Chemyo vs AdooQ — MK677 Buy Comparison
AdooQ is a legitimate biochemical reagent supplier. But its MK677 (Mesylate) is designed for cell-based assays — not practical research protocols. Here’s the full comparison.
| Standard | Chemyo MK677 | AdooQ MK677 Mesylate |
|---|---|---|
| Form sold | Free base (CAS 159634-47-6) | Mesylate salt (CAS 159752-10-0) |
| Best suited for | Liquid / oral research protocols | In vitro cell assay work |
| Purity testing (HPLC) | ✓ ≥99% every batch | ✓ ≥99% HPLC |
| Concentration testing | ✓ Independent lab | ✗ Not published |
| Public COA by lot number | ✓ Searchable online | Available on request |
| Quantity per unit | 1,250mg (50ml / 25mg/ml) | 5mg – 100mg vials |
| Price per mg | ~$0.04/mg | ~$8–16/mg |
| Ships from | USA — same-day dispatch | China / overseas |
| Delivery to USA | 3–7 days | 2–4 weeks (international) |
| Free US shipping | ✓ Orders $100+ | ✗ No |
| Induction sealed | ✓ Tamper-proof | Standard lab vial |
Why Chemyo
Why Researchers Buy MK677 From Chemyo
Chemyo sells MK677 free base (CAS 159634-47-6) — the exact form used in all Phase II/III clinical trials. AdooQ’s mesylate salt is optimized for in vitro assays, not liquid or oral protocols. Form matters.
AdooQ prices MK677 at ~$8–16/mg for assay quantities. Chemyo delivers 1,250mg at $0.04/mg — 400 times better value. Both are research grade. The difference is scale, form, and intended application.
Identity + Purity + Concentration — independently tested every batch. COA publicly searchable. Ships same business day from the USA. Free shipping on orders over $100. AdooQ ships internationally with 2–4 week delivery.
Preclinical & Clinical Research Overview
MK677 Research: What the Data Shows
MK677 has one of the most extensive GH secretagogue research profiles — spanning preclinical rodent and primate data through Phase II and III human clinical trials. All data reflects animal model and early clinical findings. MK677 is not FDA-approved.
Primary Research Areas
- ✓
GH & IGF-1 Elevation: MK677 consistently and sustainably elevates both GH and IGF-1 in animal and Phase II human studies. The ~24-hour half-life enables once-daily oral dosing in protocols — simpler than peptide-based secretagogues requiring injection.
- ✓
Lean Body Mass (Phase II Clinical): Published Phase II data in healthy elderly subjects shows statistically significant lean mass increases — the most clinically advanced GH secretagogue endpoint in published literature. Hip fracture Phase IIb data (Adunsky et al., 2011) shows functional improvement alongside lean mass gains.
- ✓
Bone Density: Phase II data shows MK677 increases bone mineral density via sustained IGF-1 elevation — studied in osteoporosis, hip fracture rehabilitation, and aging models with established efficacy signals.
- ✓
Neuroprotection (Alzheimer’s Models): Published rodent data (Int J Mol Sci, 2018) shows MK677 administration significantly reduces neuronal and synaptic loss in 5XFAD Alzheimer’s mouse models — an emerging and clinically significant research direction.
- ✓
Sleep Quality Research: Animal and early human studies show MK677 increases REM sleep duration and slow-wave sleep — linked to the known role of ghrelin and GH in sleep architecture regulation.
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Muscle Wasting / Cachexia: Phase II trials show MK677 preserves and increases lean mass in catabolic states including cancer cachexia, diet-induced catabolism, and hip fracture recovery — among the most clinically significant applications studied.
MK677 Legal Status in 2026
MK677 is legal to purchase in the USA as a research compound. Not a controlled substance, not DEA-scheduled, no prescription required for research purposes. Chemyo sells MK677 in full US regulatory compliance — research use only, not for human consumption.
Research Reference
MK677 Dosage Reference — Preclinical & Clinical Data Only
Summarized from published research. For reference only. Not a recommendation for human use.
| Research Protocol | Reported Dose | Route | Duration |
|---|---|---|---|
| GH / IGF-1 Elevation (rodent) | 3–10 mg/kg/day | Oral gavage | 7–28 days |
| Lean Body Mass (Phase II) | 10–25 mg/day | Oral | 8–24 weeks |
| Bone Density (Phase II) | 10–25 mg/day | Oral | 12–24 months |
| Hip Fracture Rehab (Phase IIb) | 25 mg/day | Oral | 24 weeks |
| Sleep Quality Research | 5–25 mg | Oral | Acute–2 weeks |
| Alzheimer’s Model (rodent) | 10 mg/kg/day | Oral gavage | 4–8 weeks |
Data from peer-reviewed preclinical and Phase I/II/IIb literature. MK677 is not FDA-approved. Human use not endorsed.
Frequently Asked Questions
MK677 Buy — Buyer FAQs
Related Strength & Recovery Research Compounds
Researchers studying the LGD-4033 and MK-677 Value Pack often also explore
RAD140,
Ostarine (MK-2866), and
YK-11 for broader anabolic and androgen receptor research models.
For growth hormone and metabolic recovery studies, MK-677 is frequently evaluated alongside
Cardarine (GW501516) in performance and body composition research protocols.
Multi-compound research workflows often require precise dosing tools such as
1ml Dropper Bottles to ensure accurate measurement and reproducibility in laboratory environments.
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